A covalently reactive group-modified peptide that specifically reacts with lysine16 in amyloid β.
نویسندگان
چکیده
Lys16 is present in the core region of the amyloid β (Aβ) self-assembly in Alzheimer's disease. Here we report that the P9-NCS peptide can covalently react with Lys16 and inhibit Aβ neurotoxic fibrillization. Moreover P9-NCS has high selectivity and it cannot react with amylin, insulin, fetal bovine serum, Q11 and MUC1 peptide.
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عنوان ژورنال:
- Chemical communications
دوره 48 85 شماره
صفحات -
تاریخ انتشار 2012